HEMATOPOIESIS AND STEM CELLS Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate
نویسندگان
چکیده
1Division of Hematology, The Children’s Hospital of Philadelphia, PA; 2Combined Degree Program and Cell and Molecular Biology Group, University of Pennsylvania, Philadelphia; 3Division of Oncology, The Children’s Hospital of Philadelphia, PA; 4Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 5Division of Hematology/Oncology, Northwestern University, Chicago, IL; and 6Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park
منابع مشابه
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.
GATA-1 and PU.1 are essential hematopoietic transcription factors that control erythromegakaryocytic and myelolymphoid differentiation, respectively. These proteins antagonize each other through direct physical interaction to repress alternate lineage programs. We used immortalized Gata1(-) erythromegakaryocytic progenitor cells to study how PU.1/Sfpi1 expression is regulated by GATA-1 and GATA...
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